polynucleotides (PN)
A measured approach to skin refinement, led by experience and evidence.
Polynucleotide treatment supports cell repair and hydration, helping your skin maintain balance over time.
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A Precise Approach to Skin Health
Polynucleotide treatment is a non-surgical procedure designed to support the skin’s natural repair process. It uses purified DNA fragments, called polynucleotides, that work with your body to hydrate and regenerate the skin from within.This therapy is well-suited for individuals who prefer subtle, steady improvements rather than dramatic or artificial changes. Over time, the skin may appear healthier, more even in tone and better supported in structure.Every treatment is thoughtfully tailored. We consider your skin’s current condition, its history, and how it responds over time. Your protocol is selected for where it needs support in the weeks ahead. The approach is measured, personal and designed to work in harmony with your long-term goals.
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Perfect for Those Looking to Restore Skin Balance
Polynucleotide treatment is often selected by clients looking to manage early signs of skin fatigue without resorting to aggressive intervention.
- Polynucleotide injections may help address:
- Fine lines and skin thinning
- Dehydration or dryness
- Mild redness or inflammation
- Loss of tone or elasticity
- Acne scarring or texture irregularities
- Dark under-eye circles
Polynucleotide injection is most often used on the face, neck, under-eye area and hands. It may also complement other treatments as part of a tailored plan.
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How Polynucleotide Injections Work
Polynucleotides are biocompatible molecules that help the skin maintain balance and hydration. Once injected, they begin to act in several ways:
- They draw in moisture to support hydration at the cellular level
- They encourage collagen production by stimulating fibroblasts
- They help repair damaged tissue over time, supporting smoother texture
The response is gradual. Visible changes may take a few weeks to appear, depending on skin condition and area treated. Results improve over multiple sessions.
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The Experience at Our Clinic
We provide polynucleotide treatment in a clinical setting, where discretion, hygiene and professionalism are core to every visit.
Our approach is guided by your skin history, lifestyle and long-term goals. Treatment plans are adjusted based on your response, not just protocol.
We use DHA-licensed products and perform all procedures in sterile rooms. Our specialists are trained in advanced injection techniques and skin analysis.
Every detail is considered to match your skin’s requirements, making this far from a typical, one-formula-fits-all treatment.
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Step-by-Step Treatment Guide
1. Before Your Session:
A one-on-one consultation will be arranged with a licensed practitioner. We review your medical history and assess your skin.
2. During the Session:
The area is cleaned and numbed. The injections are placed precisely in the areas of concern. The session typically lasts 20 to 30 minutes.
3. After the Session:
Mild swelling or redness may occur. These effects are usually temporary. Most clients resume daily activities the same day.
Gradual improvement is expected. Results often appear between the second and fourth week. For best outcomes, multiple sessions may be advised.
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The procedure at a glance
Treatment time
20–40 minutes including consultation and mapping
Anaesthetic
Usually unnecessary; topical numbing available on request
Discomfort
Low — brief pinpricks or pressure at injection sites
Downtime
Mild redness or tiny bumps for 12–24 hours; occasional light bruising
When results show
Healthier look in 1–2 weeks; firmness and texture build over 4–8 weeks and across a series
How long it lasts
Often 6–12 months with a planned maintenance schedule
Sigma approach
Male‑first dosing and placement, under‑eye expertise and smart stacking for natural, defined results without puffiness
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book a private consultation
If you’ve ever felt unsure about skin treatments, maybe from rushed consultations or results that didn’t meet your expectations. Many people have experienced clinics that apply one-size-fits-all solutions without fully understanding their unique skin needs.
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At Sigma Clinic, we approach your skin as the personal and complex part of you that it is. Our licensed professionals take the time to listen, assess and tailor each polynucleotide treatment to your skin’s condition, lifestyle, and goals. We focus on supporting your skin’s natural processes through precise, careful care.
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While individual responses vary, clients often appreciate the gradual improvements that come from a considered, expert-guided plan. Our treatments use licensed products administered in a clinical setting that prioritizes hygiene, discretion, privacy and your comfort.
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Booking a consultation with us means choosing an experience built on trust, professionalism and respect for your skin’s story.
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Your skin deserves care that’s as unique as you are. We invite you to start your personalized journey with Sigma Clinic today.
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frequently asked questions
Is the polynucleotide treatment safe?
Yes. Polynucleotide injections are considered low risk when performed by a qualified professional using approved materials.
How long do results last?
Results vary by skin type and lifestyle. Maintenance sessions may be suggested every few months.
How many treatments will I need?
Most people begin with two or three sessions, spaced a few weeks apart. A tailored plan is created after consultation.
Can I combine this with other procedures?
Yes. Polynucleotide treatment is often included in larger plans that may involve skin boosters, PRP or microneedling.
Is the polynucleotide injection procedure painful?
A numbing cream is used. Most clients find the procedure tolerable. Some discomfort may occur, but it is usually brief.
- Expect The Best
doctors & staff
Dr Jenna Burton Donald
General Practitioner
Dr Jenna Burton is the General Practitioner at Sigma Clinic, overseeing clinical governance, medical standards, and treatment protocols across aesthetics, health optimisation, and preventative medicine. British trained, she holds an MBChB from the University of Manchester and an MSc in Health Policy from Imperial College London. With over a decade of experience in the UAE, Dr Burton has worked across emergency medicine, aviation medicine, general practice, aesthetics, and wellness leadership. She is American Board qualified in Aesthetic Medicine and takes a conservative, results driven approach focused on structural balance, skin health, and natural male outcomes. Alongside aesthetics, she designs personalised health optimisation programmes integrating diagnostics, hormones, peptides, nutrition, and regenerative therapies to improve performance and longevity. At Sigma, Dr Burton ensures every treatment meets the highest clinical standards, delivering measurable progress for high performing men.
Narimane Merabet
Laser Hair Reduction Therapist/ Beauty Therapy
Narimane is a CIDESCO certified aesthetician with more than 20 years of international experience across Switzerland, Canada, and the UAE. Licensed in both aesthetics and laser therapy, she has worked with a wide range of advanced technologies used in leading clinics around the world.At Sigma, she leads the aesthetics team with precision and meticulous care, helping men achieve visible results while building long term skin health. Fluent in English, Arabic, and French, Narimane combines technical expertise with a results driven approach that aligns perfectly with Sigma’s mission of performance and optimisation.
Jaivimin Lyka Guinto
Registered Nurse
Lyca is a DHA licensed nurse with more than 10 years of experience across dermatology, plastic surgery, and hospital care. Calm, precise, and highly skilled, she assists doctors across a wide range of advanced procedures while maintaining the highest standards of safety and professionalism.As Head Nurse, Lyca oversees clinical excellence throughout Sigma, ensuring every treatment is delivered with precision and care. Her leadership and reassuring approach help clients feel confident and supported throughout their transformation journey.
Justy Thomas
Assistant Nurse/ Laser Hair Reduction
Nurse and Laser TherapistJusty brings over a decade of experience in Dubai’s leading dermatology and aesthetic clinics. Known for her accuracy, composure, and patient centred care, she specialises in delivering safe, effective laser and aesthetic treatments tailored to men’s unique skin needs. At Sigma, she provides precise, results driven treatments that help clients take control of their appearance and confidence, supporting the clinic’s mission of performance and optimisation.
Ambily
Nurse and Laser Therapist
Ambily is a highly experienced nurse with more than 11 years in critical care, outpatient services, and medical aesthetics. Her background includes leading nursing teams and providing expert laser and aesthetic treatments across renowned Dubai clinics. At Sigma, she combines her clinical expertise with a meticulous approach to treatment delivery, helping men achieve lasting results through safe, effective, and well executed care. Her professionalism and attention to detail embody the standards of excellence that define Sigma Clinic.
Rajithra Anuroop
Assistant Nurse
Rajithra is a DHA licensed nurse with more than 10 years of experience across dermatology and medical aesthetics in Dubai. She has worked in several leading clinics, assisting in procedures including injectables, regenerative therapies, skin boosters, and advanced laser treatments.At Sigma, she brings strong clinical expertise and meticulous attention to detail, ensuring every client receives safe, professional, and results driven care throughout their optimisation journey.
Celica Labarda
Massage Therapist
Celica is a DHA licensed massage therapist specialising in therapeutic recovery treatments that help clients relieve tension, improve circulation, and restore physical balance. With extensive experience working in medical and wellness clinics in Dubai, she focuses on treatments that support recovery, mobility, and overall wellbeing.
Her expertise includes deep tissue massage, lymphatic drainage, cupping therapy, reflexology, and traditional Tui Na techniques. Celica also provides restorative relaxation treatments and specialised body therapies including detoxifying mud wraps designed to support circulation and skin health.Before joining Sigma Clinic, Celica worked in leading medical and slimming therapy clinics in Dubai where she developed personalised treatment plans, supported patients through recovery programmes, and helped clients achieve measurable improvements in their health and wellbeing.Known for her warm professionalism and attentive approach to client care, Celica delivers treatments that are both deeply restorative and highly effective.At Sigma Clinic, Celica helps high performing men relieve physical stress, recover faster, and maintain their overall wellbeing.The Sigma Experience
Consult → Diagnose → Plan → Execute → Maintain
Consult
A straightforward, open discussion about the look you’re aiming for and the one you’d prefer to avoid.
Diagnose
A high-resolution facial scan analysing texture, pigmentation, ageing patterns, symmetry, pore size and structure. This removes guesswork and shows exactly where the biggest improvements sit.
Plan
A prioritised roadmap outlining the highest-impact treatments first, with optional upgrades depending on how fast you want to progress.
Execute
Precision treatments delivered with masculine proportions in mind, keeping everything natural, controlled and balanced.
Maintain
A sustainable long term routine so your results stay sharp with minimal effort.
Join us in the pursuit of physical and spiritual excellence.